The fastest, most direct and best way will be an overnight bus operated by www.alsa.es.
Dept: SEVILLA - 19/04/2008 - 23:59
Arr: COIMBRA - 20/04/2008 - 09:30
Price: € 50.00
There is then a train leaving from Coimbra Parque Station at 10:19 arriving Miranda do Corvo at 10:54.
There are no direct train services or low cost flights between Seville and Lisbon or Porto. The above solution is about the only direct effective service.
If you go to my blog at:
http://barlaventostravelblog.blogspot.com/
You will find a copy of this answer.
Below you will find a png file with the alsa.es timetable for the route Seville - Coimbra. If you click it you should be able to view it.
Also on the blog if you scroll down on the right till you come to the panel:
>> Algarve & Portugal - Travel Transport Links
You will find a link entitled
"Train Timetable - Coimbra - Miranda do Corvo"
Click on it and you will be able to download in pdf format the official timetable for the train service.
Hope this helps
